1915 the new Archbishop of Malta, Mgr. M. Caruana, appointed him as
his personal secretary. Between
1918-20 he also served as Rector of the Major Seminary of Malta in Mdina.
During this period he was one of the Maltese leaders during the Sette Giugno
1920 De Piro was nominated as Dean of the Cathedral Chapter.Malta
was given a new Constitution - that of the National Assembly.
He was a hard working member of this same assembly. In 1922 served as a substitute parish-priest for some months in Gudja.
During this period he was also made director of the following
1922: St. Joseph's Home, Hamrun.
1922: Jesus of Nazareth Institute, Zejtun.
1925: St. Joseph's Home, Ghajnsielem
(where he later founded the St.
Joseph Band Club in 1928)
1925: The home for Little Children, St. Venera.
1927: St. Francis de Paule Institute, B'Kara.
In 1930 he served as intermediary between the
local Church and Lord Strickland.
1932/33 he also served as a Senator in the third Maltese Parliament. Mgr. De Piro, aged 56, died
on the 17 September of 1933 after collapsing
during a liturgical service at St. Cajetan's Parish Church, Hamrun.